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. 2019 Oct 13;11(10):1549. doi: 10.3390/cancers11101549

Figure 3.

Figure 3

miR-196a downregulation impairs tumor growth of xenotransplants and pulmonary metastasis of PLC cells. (A) The upper row shows harvested tumors from mice that received subcutaneous implantation of PLC cells without knockdown, and the lower row shows tumors from xenografts of implanted PLC cells with miR-196a knockdown (top). The periodically measured sizes of HCC xenografts had a trend of lower growth curves for PLC cells with miR-196a knockdown (bottom). (B) Knockdown of miR-196a led to the suppression of the intratumoral microvessels, assessed by CD31-positive tubes (bottom, 200× magnification, **p < 0.01). (C) The upper row shows lungs from mice that received PLC without knockdown, and the lower row shows lungs from mice receiving PLC with miR-196a knockdown, which showed a decreased extent of pulmonary metastasis (yellow arrows). The diameter of the mesh opening was 0.2 mm (top). The number of metastatic nodules in the sectioned lungs was significantly decreased after knockdown of miR-196a (**p < 0.01).