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. 2019 Oct 13;11(10):1549. doi: 10.3390/cancers11101549

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Knockdown of miR-196a modulated epithelial–mesenchymal transition regulators and stemness genes in PLC cells. (A) Western blotting indicated that miR-196a downregulation led to a decrease of Slug and Twist. (B) Immunohistochemistry revealed that the levels of Slug and Twist were reduced in the xenografts derived from PLC-miR196a-KD compared with those from PLC-miR196a-C (original magnification, ×200). (C) Western blotting showed that downregulation of miR-196a reduced the levels of Oct4 and Sox2 in PLC. (D) Immunohistochemistry showed that downregulation of miR-196a reduced Oct4 and Sox2 expression in the subcutaneous xenografts derived from miR196a-KD PLC cells compared with those from miR196a-C PLC cells (original magnification, ×200).