Table 2.

Cox proportional hazard analyses for recurrence of hepatocellular carcinoma.

Variable	Univariate Analyses			Multivariate Analyses
	Crude HR	95% CI	p Value	Adjusted HR	95% CI	p Value
Host factors
Age ≥ 50	0.991	0.542–1.811	0.9756
Male	1.074	0.474–2.434	0.8634
Cirrhosis	0.990	0.537–1.825	0.973
Diabetes mellitus	1.238	0.521–2.942	0.629
Viral factors
Positive HBeAg	0.809	0.306–2.141	0.6694
HBV DNA ≥ 104 copies/mL	1.978	0.776–5.040	0.1529
HBV genotype C vs. B	1.585	0.849–2.957	0.1481
Tumor factors
Tumor size ≥ 5 cm	1.422	0.773–2.613	0.2573
AFP ≥ 20 ng/mL	1.327	0.711–2.474	0.3741
Well differentiation	0.893	0.123–6.504	0.9111
Multinodularity	1.799	0.900–3.595	0.0964
Microvascular invasion	3.429	1.831–6.419	<0.001	4.582	2.215–9.479	<0.001
Macrovascular invasion	2.196	0.853–5.656	0.1031
High miR-196a expression	2.124	1.148–3.929	0.016	2.395	1.207–4.752	0.0125

AFP: alpha-fetoprotein; CI: confidence interval; HBV: hepatitis B virus; HR: hazard ratio.