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. 2019 Oct 2;11(10):1488. doi: 10.3390/cancers11101488

Figure 7.

Figure 7

Mouse Nrf2−/− promotes a mesenchymal phenotype in primary lung alveolar cells. (A) Gene set enrichment of Nrf2 KO RNA expression indicate correlation with multiple EMT signatures. (B) Lung alveolar cell RNA expression comparing Nrf2 knockout vs. control (column 1), is compared with mean log2 TGFβ E and M state changes in the four lung adenocarcinoma cell models (column 2) and mean Zeb1 and Snail1 driven EMT changes in two H358 models. Data are expressed as percent maximum change to scale microarray and RNAseq dynamic ranges. EMT related RNAs are bolded. (C) Correlation of Nrf2 KO RNA expression with EMT RNA changes in the four NSCLC models.