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. 2019 Oct 17;11(10):1581. doi: 10.3390/cancers11101581

Figure 3.

Figure 3

Synergism between irinotecan (Irino) and AZD8055, and between irinotecan (Irino) and AZD2014 on colon cancer cell viability. Combination index (CI) showing the synergistic effect of irinotecan (0.5 µM to 20 µM), AZD8055, or AZD2014 (25 nM to 1000 nM) on colon cancer cells. CI was determined from Chou and Talalay method, according to a constant ratio model. For a given efficacy (affected fraction, Fa), the combination index (CI) defines whether the association is synergistic (CI <1), additive (CI = 1) or antagonist (CI >1).