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. 2019 Sep 30;11(10):1476. doi: 10.3390/cancers11101476

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Chemoresistance Index differentiating good and poor responders. K-means clustering built on the CI. The algorithm identifies two groups of patients: cluster 1 includes subjects showing high CI toward CBDCA, CDDP, and DOXO and low CI for VP-16 and VCR; cluster 2 contains patients showing opposite features, with low CI toward CBDCA, CDDP, and DOXO and slightly high CI to VP-16 and VCR. Event-free survival (EFS) defined the response to induction chemotherapy: patients that reported a relapse, a progression, or died are addressed as poor responders. The association between the identified clusters and EFS is significant (p value < 0.03), showing that the CI is indicative of a poor response.