Table 2.
Differentially expressed exo-miRNAs at the end of induction chemotherapy.
| miRNA ID a | Mean ∆CT End | Mean ∆CT Onset | Mean RQ End | Mean RQ Onset | Fold Change b | Adjusted p Value c |
|---|---|---|---|---|---|---|
| hsa-miR-376a | 3.28 | 1.28 | 0.10 | 0.41 | −2.0 | 5.30E−08 |
| hsa-miR-150 | −6.04 | −7.60 | 65.87 | 194.19 | −1.6 | 9.87E−08 |
| hsa-miR-376c | 2.69 | 0.70 | 0.16 | 0.62 | −2.0 | 1.48E−07 |
| hsa-miR-132 | 1.33 | −0.55 | 0.40 | 1.47 | −1.9 | 5.45E−07 |
| hsa-miR-130a | 1.36 | −0.49 | 0.39 | 1.40 | −1.8 | 1.21E−05 |
| hsa-miR-539 | 2.61 | 0.85 | 0.16 | 0.55 | −1.8 | 3.22E−05 |
| hsa-miR-342-3p | −2.59 | −3.70 | 6.03 | 12.96 | −1.1 | 4.81E−05 |
| hsa-miR-192 | 1.40 | 0.06 | 0.38 | 0.96 | −1.3 | 5.95E−05 |
| hsa-miR-340 | 3.02 | 1.78 | 0.12 | 0.29 | −1.2 | 5.95E−05 |
| hsa-miR-320 | −4.01 | −4.97 | 16.10 | 31.28 | −1.0 | 7.29E−05 |
| hsa-let-7g | 0.24 | −1.06 | 0.85 | 2.08 | −1.3 | 9.93E−05 |
| hsa-miR-590-5p | 0.96 | −0.30 | 0.51 | 1.23 | −1.3 | 9.93E−05 |
| hsa-miR-152 | 2.44 | 1.22 | 0.18 | 0.43 | −1.2 | 2.27E−04 |
| hsa-miR-146b | −3.45 | −4.37 | 10.91 | 20.74 | −0.9 | 2.27E−04 |
| hsa-miR-20a | −3.86 | −5.32 | 14.56 | 39.97 | −1.5 | 3.64E−04 |
| hsa-miR-25 | −0.31 | −1.69 | 1.24 | 3.23 | −1.4 | 3.64E−04 |
| hsa-miR-26b | 0.19 | −1.15 | 0.88 | 2.22 | −1.3 | 3.64E−04 |
| hsa-miR-324-3p | 1.73 | 0.62 | 0.30 | 0.65 | −1.1 | 4.52E−04 |
| hsa-miR-199a-3p | −0.01 | −1.41 | 1.01 | 2.65 | −1.4 | 4.95E−04 |
| hsa-miR-106b | −0.59 | −1.75 | 1.50 | 3.36 | −1.2 | 5.83E−04 |
| hsa-miR-19b | −4.65 | −6.15 | 25.11 | 71.00 | −1.5 | 6.23E−04 |
| hsa-miR-374 | −1.50 | −2.61 | 2.82 | 6.11 | −1.1 | 6.54E−04 |
| hsa-miR-29c | 2.42 | 1.03 | 0.19 | 0.49 | −1.4 | 9.50E−04 |
| hsa-miR-20b | −1.84 | −2.92 | 3.57 | 7.55 | −1.1 | 1.03E−03 |
| hsa-miR-26a | −1.83 | −3.01 | 3.57 | 8.07 | −1.2 | 1.09E−03 |
| hsa-miR-140-3p | 3.24 | 2.38 | 0.11 | 0.19 | −0.9 | 1.65E−03 |
| hsa-miR-18a | 1.47 | 0.31 | 0.36 | 0.80 | −1.2 | 1.65E−03 |
| hsa-miR-185 | 1.08 | −0.04 | 0.47 | 1.03 | −1.1 | 1.65E−03 |
| hsa-miR-195 | −0.71 | −1.81 | 1.63 | 3.50 | −1.1 | 1.69E−03 |
| hsa-miR-142-3p | −2.80 | −4.16 | 6.95 | 17.86 | −1.4 | 2.02E−03 |
| hsa-miR-21 | −1.44 | −2.66 | 2.72 | 6.31 | −1.2 | 2.30E−03 |
| hsa-miR-652 | 1.07 | −0.15 | 0.47 | 1.11 | −1.2 | 2.41E−03 |
| hsa-miR-19a | −0.08 | −1.40 | 1.06 | 2.65 | −1.3 | 2.43E−03 |
| hsa-let-7e | −2.27 | −3.31 | 4.81 | 9.94 | −1.0 | 2.55E−03 |
| hsa-miR-106a | −5.59 | −6.46 | 48.08 | 88.20 | −0.9 | 2.55E−03 |
| hsa-miR-660 | 1.40 | 0.29 | 0.38 | 0.82 | −1.1 | 2.99E−03 |
| hsa-miR-598 | 1.94 | 0.64 | 0.26 | 0.64 | −1.3 | 3.56E−03 |
| hsa-let-7d | 0.11 | −0.81 | 0.93 | 1.75 | −0.9 | 3.73E−03 |
| hsa-miR-24 | −4.99 | −5.75 | 31.85 | 53.81 | −0.8 | 5.38E−03 |
| hsa-miR-17 | −5.42 | −6.41 | 42.81 | 85.03 | −1.0 | 5.47E−03 |
| hsa-miR-483-5p | −0.30 | −1.11 | 1.23 | 2.16 | −0.8 | 5.67E−03 |
| hsa-miR-30b | −2.76 | −3.76 | 6.78 | 13.54 | −1.0 | 5.99E−03 |
| hsa-miR-301 | 1.70 | 0.70 | 0.31 | 0.62 | −1.0 | 6.28E−03 |
| hsa-miR-186 | −2.53 | −3.38 | 5.79 | 10.40 | −0.8 | 8.42E−03 |
| hsa-miR-331 | −1.40 | −2.13 | 2.63 | 4.38 | −0.7 | 8.98E−03 |
| hsa-miR-27a | 0.15 | −0.82 | 0.90 | 1.76 | −1.0 | 9.19E−03 |
| hsa-miR-15b | −0.63 | −1.60 | 1.55 | 3.04 | −1.0 | 9.41E−03 |
| hsa-miR-28 | 2.12 | 1.28 | 0.23 | 0.41 | −0.8 | 1.14E−02 |
| hsa-miR-345 | 0.70 | 0.05 | 0.61 | 0.96 | −0.6 | 1.28E−02 |
| hsa-miR-30c | −3.10 | −4.03 | 8.59 | 16.32 | −0.9 | 1.29E−02 |
| hsa-miR-103 | 0.95 | 0.13 | 0.52 | 0.91 | −0.8 | 1.30E−02 |
| hsa-miR-193b | 1.91 | 1.21 | 0.27 | 0.43 | −0.7 | 1.34E−02 |
| hsa-miR-29a | −0.84 | −1.54 | 1.78 | 2.91 | −0.7 | 1.64E−02 |
| hsa-miR-99b | 2.30 | 1.69 | 0.20 | 0.31 | −0.6 | 1.64E−02 |
| hsa-miR-328 | 0.69 | −0.16 | 0.62 | 1.12 | −0.9 | 1.80E−02 |
| hsa-miR-744 | 0.24 | −0.53 | 0.85 | 1.45 | −0.8 | 2.78E−02 |
| hsa-miR-425-5p | 0.38 | −0.23 | 0.77 | 1.18 | −0.6 | 3.23E−02 |
| hsa-miR-92a | −2.30 | −3.03 | 4.94 | 8.15 | −0.7 | 3.23E−02 |
| hsa-miR-16 | −5.99 | −6.86 | 63.78 | 116.19 | −0.9 | 3.25E−02 |
| hsa-miR-142-5p | 2.39 | 1.66 | 0.19 | 0.32 | −0.7 | 3.38E−02 |
| hsa-miR-221 | 0.16 | −0.73 | 0.90 | 1.66 | −0.9 | 4.11E−02 |
| hsa-miR-146a | −5.33 | −5.98 | 40.31 | 62.91 | −0.6 | 4.30E−02 |
a List of differentially expressed exo-miRNAs; b Fold change defined as –∆∆CT value. Fold change lower than 0 indicates a downregulation. Fold change higher than 0.58 or lower than −0.58 was considered significant; c T test p value adjusted for multiple hypothesis testing using Benjamini-Hockberg. p value lower than 0.05 is considered significant.