Figure 6.

Evaluation of honokiol effects on cellular apoptosis in kidney of cisplatin-injured animals. TUNEL assay was used to evaluate the level of cellular apoptosis. (A) In both cortex and medulla, minimal amounts of apoptotic cells were observed in control and nHNK alone groups (less than 1% in these conditions, B,C). A dramatic increase of apoptotic cells was detected in both the cortex (12.3%, B) and medulla (26.9%, C) regions of the kidney, however, when nHNK was given to cisplatin-treated animals, significant decreases in apoptotic cells were observed (1.98% and 4.7% in the cortex and medulla regions, respectively).