Table 1.

Kidney physiological parameters (value ± S.D.).

Parameters		Week 0	Week 2	Week 4	Week 6
Body weight (g)	G1 Control	36.26 ± 1.41	35.26 ± 1.47	35.34 ± 1.47	33.10 ± 0.93
	G2 nHNK	34.15 ± 1.35	35.03 ± 1.35	33.35 ± 1.45	32.71 ± 1.29
	G3 Cisplatin	37.74 ± 0.93	35.46 ± 1.14	32.35 ± 1.45	29.18 ± 1.46*
	G4 Cis/nHNK	37.39 ± 1.71	35.28 ± 1.24	34.43 ± 0.84	33.55 ± 1.08
Urine Osmolarity (mOsmol)/kg	G1 Control	3100.0 ± 50	2516.7 ± 36	3140.0 ± 407	2856.3 ± 25
	G2 nHNK	3050.0 ± 351	2425.0 ± 70	2891.7 ± 436	3390 ± 590
	G3 Cisplatin	3088.2 ± 456	1735.9 ± 78	1168.1 ± 83	1558.3 ± 183
	G4 Cis/nHNK	2489.4 ± 347	1815.5 ± 198	1087.5 ± 75	1587.5 ± 188
Serum BUN (mg/dl)	G1 Control	20.84 ± 2.49	25.20 ± 2.35	21.6 ± 1.63	20.40 ± 1.91
	G2 nHNK	22.25 ± 3.10	24.25 ± 3.30	23.50 ± 3.90	18.25 ± 1.25
	G3 Cisplatin	20.81 ± 1.79	20.00 ± 2.12	27.33 ± 3.18	47.00 ± 13.8*
	G4 Cis/nHNK	21.50 ± 4.00	20.75 ± 1.25	22.50 ± 4.17	18.00 ± 4.17
Serum creatinine (mg/dl)	G1 Control	0.160 ± 0.02	0.130 ± 0.03	0.130 ± 0.03	0.140 ± 0.04
	G2 nHNK	0.130 ± 0.03	0.130 ± 0.03	0.100 ± 0.00	0.130 ± 0.03
	G3 Cisplatin	0.100 ± 0.00	0.130 ± 0.02	0.170 ± 0.02	0.230 ± 0.05*
	G4 Cis/nHNK	0.100 ± 0.00	0.143 ± 0.02	0.167 ± 0.03	0.100 ± 0.00
Serum indoxyl sulfate (ppm)	G1 Control	2.017 ± 0.27	3.043 ± 0.55	1.988 ± 0.35	2.600 ± 0.58
	G2 nHNK	2.302 ± 0.33	2.911 ± 0.61	1.810 ± 0.32	1.584 ± 0.23
	G3 Cisplatin	2.021 ± 0.56	5.074 ± 2.08	7.694 ± 0.95*	8.591 ± 0.51*
	G4 Cis/nHNK	2.397 ± 0.51	4.491 ± 1.64	5.256 ± 0.85	5.058 ± 0.95

1. Ctrl.: vehicle control (100 μL corn oil); nHNK: 5 mg/kg liposome-encapsulated honokiol alone, IP; Cisplatin: 10mg/kg cisplatin alone, IP; Cis/nHNK: 10 mg/kg cisplatin + 5 mg/kg Honokiol. 2. * indicates the G3 cisplatin group is significantly different (p < 0.05) from the G4 (treatment) cisplatin + honokiol group.