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. 2019 Oct 11;11(10):1535. doi: 10.3390/cancers11101535

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Immunoexpression of CTLA-4 and PD-L1 in tumor cells of testicular germ cell tumor subtypes. CTLA-4 immunoexpression intensity in tumor cells among seminomas and non-seminomas (A) and among the various histotypes (B). PD-L1 positivity in tumor cells among seminomas and non-seminomas (C) and among the various histotypes (D). Abbreviations: TC—tumor cells; NS—non-seminoma; SE—seminoma; EC—embryonal carcinoma; YST—postpubertal-type yolk sac tumor; TE—postpubertal-type teratoma; CH—choriocarcinoma. * refers to p < 0.05; ** refers to p < 0.01; *** refers to p < 0.001; **** refers to p < 0.0001.