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. 2019 Oct 8;11(10):1508. doi: 10.3390/cancers11101508

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Orthopedia homeobox (OTP) immunohistochemistry of pulmonary carcinoids and neuroendocrine cell hyperplasia (NECH). (A) Representative image of nuclear OTP (nOTP) and cytoplasmic OTP (cOTP) staining in a typical carcinoid; (B) Representative image of a carcinoid tumor harbouring only cytoplasmic immunoreactivity for OTP; (C) Representative image of a carcinoid tumor with no OTP immunoreactivity; (D) Representative image of both nOTP and cOTP staining in NECH (magnification 200×) [14,16].