Table 1.
Overview of the characteristics of studies that analysed OTP expression in pulmonary carcinoids using immunohistochemistry.
| Study Population | Histology | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Study, Year [Ref] |
Initial Cohort | Included in Analysis | Age (years) | Gender (n) | DIPNECH | TC | AC | HGNECs | WHO Classification (year) | Normal Tissue Included (n) | Other (NE) Tissues Included (n) |
| Hanley et al., 2018 [18] |
63 | 59 | 26–91 | M(24), F(39) | 0 | 9 | 6 | 1 | Yes (2015) | No | Yes (51) |
| Nonaka et al., 2016 * [17] |
159 | 159 | 21–83 | M(62), F(97) | 7 | 123 | 21 | 104 | Yes (2015) | Yes (n/a) | Yes (758) |
| Papaxoinis et al., 2018 * [19] | 166 | 166 | 16–83 | M(62), F(104) | 16 | 132 | 34 | 0 | Yes (2015) | No | No |
| Papaxoinis et al., 2017 * [15] | 108 | 86 | 21–83 | M(44), F(64) | 8 | 69 | 17 | 0 | Yes (2015) | No | No |
| Swarts et al., 2013 [14] |
352 | 348 | 16–83 | M(130), F(159) | 0 | 225 | 63 | 59 | Yes (2003) | Yes (4) | Yes (9) |
| Yoxtheimer et al., 2018 [20] | 50 | 50 | 21–87 | M(30), F(20) | 0 | 8 | 6 | 16 | Yes (2015) | No | Yes (20) |
| Viswanathan et al., 2019 [21] | 60 | 57 | 32–86 | M(31), F(29) | 0 | 11 | 12 | 19 | Yes (2015) | No | Yes (18) |
* studies performed in the same study population. Abbreviations: Ref, reference; n, number; M, male; F, female; DIPNECH, diffuse idiopathic neuroendocrine cell hyperplasia; TC, typical carcinoid; AC, atypical carcinoid; HGNECs, high-grade neuroendocrine carcinomas e.g. large cell neuroendocrine carcinoma and small cell lung carcinoma; WHO, world health organization; NE, neuroendocrine; IHC, immunohistochemistry; n/a, not applicable.