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. 2019 Oct 5;11(10):1496. doi: 10.3390/cancers11101496

Figure 4.

Figure 4

EGCG enhances the cell growth inhibitory effect of gemcitabine in pancreatic cancer cells. Combination index (CI) plots of EGCG (20, 40, 60 µM) in combination with gemcitabine (1, 10, 20 and 40 nM), abraxane (1, 10, 20 and 40 nM), 5-Fluorouracil (1, 10, 20 and 40 µM), irrinotecan (1, 10, 20 and 40 µM), and oxialiplatin (1, 10, 20 and 40 µM) in Panc-1 (left) and MIA PaCa-2 (right) cells. Drug interactions were quantitatively determined using the Chou–Talalay method, and CI < 1, =1, and >1 indicates synergism, additive and antagonism effect, respectively. Of note, the CI value dots depicted are based on concentrations of EGCG and the chemotherapeutic drugs shown on Table S1.