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. 2019 Sep 26;11(10):1440. doi: 10.3390/cancers11101440

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Promoter-associated chromatin looping identifies HiChIP target genes at the 9p21.3 locus. Promoter-associated loops were intersected with endometrial cancer risk CVs (coloured red), revealing loops (purple) that interact with the promoters of MIR31HG (in E6E7hTERT and ARK-1 cells), CDKN2A (in E6E7hTERT and ARK-1 cells), CDNK2B-AS1 (in E6E7hTERT and ARK-1 cells) and CDKN2B (in ARK-1 cells). CDK2NA and the non-coding anti-sense gene CDKN2B-AS1 are encoded on opposite DNA strands and share a promoter.