Table 3.
HiChIP target genes at endometrial cancer risk loci.
| Risk Locus | HiChIP Target Genes | Nearest Gene(s) to CVs 1 |
|---|---|---|
| 1p34.3 | GNL2, C1orf122 | GNL2, RSPO1 |
| 2p16.1 | BCL11A | BCL11A |
| 8q24.1 | MIR1207, PVT1, LINC00824 | LINC00824 |
| 9p21.3 | CDKN2A, CDKN2B, CDKN2B-AS1, MIR31HG | CDKN2B-AS1 |
| 11p13 | WT1, WT1-AS, CD59, PAX6, RCN1 | WT1-AS |
| 12p12.1 | BHLHE41, PTHLH, SSPN, LRMP | SSPN |
| 12q24.11 | SH2B3, PHETA1, ACAD10, ARPC3, BRAP, IFT81, LINC02356 | SH2B3, ATXN2 |
| 12q24.21 | TBX3 | TBX3 |
| 15q15.1 | SRP14, SRP14-AS1, BMF, BAHD1, CCDC9B, GPR176, KNSTRN, PAK6, PLCB2, PLCB2-AS1, THBS1, EIF2AK4, CHST14, DISP2, FSIP1, INAFM2, PLA2G4B, RASGRP1, SPINT1, ANKRD63, PHGR1, SPINT1-AS1, C15orf56 | SRP14, SRP14-AS1, EIF2AK4 |
| 15q21.2 | DMXL2, TRPM7, TNFAIP8L3 | CYP19A1 |
| 17q11.2 | RAB11FIP4, MIR193A, TEFM, RNU6ATAC7P | RAB11FIP4, NF1, EVI2A, EVI2B |
| 17q12 | HNF1B, DUSP14, MRM1, MRPL45, SRCIN1, TBC1D3, C17orf78 | HNF1B |
| 17q21.32 | SNX11, MIR1203, SKAP1-AS1, SKAP1, CBX1, HOXB1, HOXB2, HOXB3, HOXB4, HOXB5, HOXB6, HOXB7, HOXB8, HOXB9, HOXB13, HOXB-AS1, HOXB-AS3, HOXB-AS4, PRR15L, CDK5RAP3, LRRC46, MRPL10, NFE2L1, SCRN2, CALCOCO2, COPZ2, DLX3, KPNB1, PNPO, SNF8, SP2, SP2-AS1, SP6, MIR10A, MIR152, MIR196A1, MIR3185, PHOSPHO1 | SNX11, MIR1203, SKAP1-AS1, SKAP1, CBX1 |
1 At some loci, CVs are coincident with multiple genes. Underlined candidate target genes are supported by HiChIP data from multiple cell lines.