Table 1.
Single dose serum pharmacokinetics of 2 mg/kg oral dose of cannabidiol (CBD) enriched soft chew of individual dogs with mean and standard error.
| Dog | Cmax (ng/mL) | Tmax (h) | T1/2 el. (h) | AUC 0-t (ng-h/mL) | MRT (h) |
|---|---|---|---|---|---|
| 1 | 266 | 2 | 1.8 | 1494 | 2.6 |
| 2 | 315 | 1 | 0.5 | 1431 | 0.7 |
| 3 | 242 | 1 | 0.8 | 803 | 1.1 |
| 4 | 151 | 2 | 1.1 | 845 | 1.6 |
| 5 | 531 | 1 | 0.8 | 1912 | 1.2 |
| Mean ± SEM | 301 ± 63 | 1.4 ± 0.2 | 1.0 ± 0.2 | 1297 ± 210 | 1.4 ± 0.3 |
Cmax = maximum concentration; Tmax = time of maximum concentration; T1/2 el = half-life of elimination; AUC 0-t = area under the curve (time 0 to 24 h); MRT = median residence time.