Table 4.
Dog (n = 8) mean and SEM of serum chemistry parameters immediately prior to (week 0), 4 weeks, 8 weeks and 12 weeks of an oral 2 mg/kg CBD dose twice daily using a CBD-rich hemp product.
| Serum Chemistry (Ref Range) ** | Week 0 | Week 4 | Week 8 | Week 12 | p-Value |
|---|---|---|---|---|---|
| TP (5.0–7.4 g/dL) | 6.1 ± 0.1 | 5.9 ± 0.2 | 6.3 ± 0.2 | 6.0 ± 0.2 | 0.65 |
| Albumin (2.7–4.4 g/dL) | 3.5 ± 0.1 | 3.5 ± 0.1 | 3.5 ± 0.1 | 3.4 ± 0.1 | 0.22 |
| Globulin (1.6–3.6 g/dL) | 2.6 ± 0.1 | 2.5 ± 0.1 | 2.9 ± 0.1 | 2.6 ± 0.2 | 0.18 |
| AST (15–66 U/L) | 27 ± 2 | 25 ± 2 | 23 ± 2 | 25 ± 1 | 0.45 |
| ALT (12–118 U/L) | 34 ± 3 | 27 ± 2 | 35 ± 10 | 28 ± 3 | 0.57 |
| ALP (5–131 U/L) | 39 ± 6 | 46 ± 7 | 56 ± 10 | 61 ± 13 | 0.09 |
| GGT (1–12 U/L) | 4 ± 0 | 3 ± 0 | 4 ± 0 | 4 ± 0 | 0.72 |
| BUN (6–31 mg/dL) | 11 ± 1 | 10 ± 1 | 11 ± 1 | 11 ± 0 | 0.82 |
| Creatinine (0.5–1.6 mg/dL) | 0.5 ± 0.0 | 0.5 ± 0.0 | 0.5 ± 0.0 | 0.5 ± 0.0 | 0.36 |
| Phosphorous (2.5–6.0 mg/dL) | 4.3 ± 0.2 | 4.1 ± 0.2 | 4.2 ± 0.3 | 4.0 ± 0.2 | 0.11 |
| Glucose (70–138 mg/dL) | 97 ± 3 | 92 ± 2 | 102 ± 3 | 99 ± 2 | 0.16 |
| Calcium (8.9–11.4 mg/dL) | 10.4 ± 0.1 | 10.0 ± 0.1 | 10.2 ± 0.1 | 10.1 ± 0.1 | 0.16 |
| Magnesium (1.5–2.5 mEq/L) | 1.6 ± 0.0 | 1.6 ± 0.0 | 1.6 ± 0.0 | 1.6 ± 0.0 | 0.11 |
| Sodium (139–154 mEq/L) | 148 ± 0 | 148 ± 0 | 146 ± 1 | 148 ± 0 | 0.58 |
| Potassium (3.6–5.5 mEq/L) | 4.3 ± 0.1 | 4.4 ± 0.1 | 4.3 ± 0.1 | 4.2 ± 0.0 | 0.23 |
| Chloride (102–120 mEq/L) | 113 ± 0 | 113 ± 1 | 111 ± 1 | 113 ± 1 | 0.74 |
| Cholesterol (92–324 mg/dL) | 182 ± 13 | 203 ± 12 | 211 ± 12 | 212 ± 17 | 0.06 |
| Triglycerides (29–291 mg/dL) | 48 ± 4 | 44 ± 4 | 43 ± 5 | 46 ± 6 | 0.44 |
| Creatine Kinase (59–895 U/L) | 130 ± 16 | 142 ± 43 | 83 ± 5 | 97 ± 5 | 0.10 |
** Klaassen, J.K. Reference values in veterinary medicine. Lab Med, 1999, 30, 194–197.