Table 1.

Comparison of THALES and SOCRATES study designs

Comparison	THALES n ∼13,000	SOCRATES n = 13,199
Dose regimen	Ticagrelor vs. placebo on top of aspirin (DAPT)	Ticagrelor vs. aspirin (single antiplatelet therapy)
Study duration	30 days + 30 days follow-up	90 days + 30 days follow-up
Population	TIA with ABCD2 score ≥ 6 and/or ipsilateral stenosis and acute ischemic stroke NIHSS ≤5	TIA with ABCD2 score ≥ 4 and/or ipsilateral stenosis and acute ischemic stroke NIHSS ≤5
Endpoints
Primary efficacy Secondary efficacy Safety	Stroke + death Ischemic stroke, disability (mRS) Severe bleeding and AEs leading to discontinuation of study medication	Stroke + myocardial infarction + death Ischemic stroke, net clinical outcome Major bleeding and AEs leading to discontinuation of study medication

DAPT: dual antiplatelet therapy; mRS: modified Rankin Scale; NIHSS: National Institutes of Health Stroke Scale; TIA: transient ischemic attack.