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. 2019 Oct 12;11(10):0. doi: 10.3390/cancers11101547

Table 3.

Recent studies comparing clinical outcomes of adjuvant chemoradiation therapy vs. other strategies in resected pancreatic cancer.

Author Year Clinical Study Design N of Patients Study Groups RT Dose RT Technique Drugs Key Results
Morganti et al. [40] 2014 retrospective 955 3: RT, CT, or CRT 45-60 Gy na fluoropyrimidines OS: CRT 39.9 mts
CT 27.8 mts
RT 24.8 mts (p > 0.001)
Parikh et al. [41] 2015 retrospective 1130 3: surgery, CT, CRT 50 Gy na gemcitabine OS:
CT vs. surgery
HR 0.71 (0.57–0.89)
CRT vs. surgery
HR 0.84 (0.69–1.02)
Rutter et al. [39] 2015 retrospective 6165 2: CT or CRT 50 Gy na na CRT vs. CT
OS: 23.3 vs. 20 mts
5-y OS: 19.6% vs. 16.5% (p 0.001)
Osipov et al. [42] 2017 retrospective 102 2: CT or CRT na na na >2 mm resection margin vs. <2 mm:
Local RFS: HR 0.20 (0.05–0.88) OS: HR 0.31 (0.14–0.74)
Kanji et al. [43] 2018 retrospective 102 2: CT or CT-CRT 50 Gy na gemcitabine and taxanes, then fluoropyrimidines CCRT vs. CT
OS: HR 0.08 (p < 0.001)
DFS: HR 0.23 (p 0.001)
Hsieh et al. [44] 2018 prospective 588 3: CCRT, CRT, CT 50 Gy IMRT gemcitabine OS:
CCRT vs. CT
HR 0.40 (0.31–0.50)
CRT vs. CT HR 0.31 (0.24–0.40)
CRT vs. CCRT (p 0.014)
Xu et al. [45] 2018 retrospective 804 3: surgery alone, CT, CRT 50 Gy IMRT gemcitabine CRT vs. no CRT:
OS 23.7 vs. 17.0 mts
p < 0.001
RFS 12.2 vs. 8.5 mts
p < 0.001
Ma et al. [46] 2019 retrospective 5667 3: CCRT, CRT, CT >45 Gy na 5FU or gemcitabine OS:
CCRT vs. CT 23.3 vs. 20.0
CCRT vs. CRT 23.4 vs. 20.8 (p > 0.001)

Abbreviations: 5FU = 5-fluorouracil; CT = chemotherapy; CCRT = chemotherapy followed by concurrent chemoradiation therapy (CRT); DFS = disease-free survival; mts = months; OS = overall survival; na =, not available; RFS = relapse-free survival; RT = radiation therapy; IMRT = intensity-modulated radiation therapy.