Table 2.

Classical Ehlers–Danlos syndromes (EDS)–clinical criteria.

Major criteria	1. Skin hyperextensibility and atrophic scarring 2. Generalized joint hypermobility
Minor criteria	1. Easy bruising
	2. Soft, doughty skin
	3. Skin fragility (or traumatic splitting)
	4. Molluscoid pseudotumors
	5. Subcutaneous spheroids
	6. Hernia (history thereof)
	7. Epicanthal folds
	8. Complications of joint hypermobility (e.g., sprains, luxation/subluxation, pain, flexible flatfoot)
	9. Family history of a first-degree relative who meets clinical criteria

Adapted from Malfait et al. [29].