Table 1.
Biobanking and patient overview.
| Patients Characteristics (n = 382) | ||||||
|---|---|---|---|---|---|---|
| Male | Female | Mean Age | 5-year Follow-up Rate | 5-year Relapse-free Survival | 5-year Survival Rate | |
| Adenoma (n = 32) | 23 (71.9%) | 9 (28.1%) | 69.0 (28–85) | n.a. | n.a. | n.a. |
| CRC (n = 350 ◆) | 207 (59.1%) | 143 (40.9%) | 72.0 (21–98) | 236 (67.4%) | 43.2% | 51.3% |
| UICC I (n = 74; 21.1%) | 42 (56.8%) | 32 (43.2%) | 73.0 (28–98) | 47 (63.5%) | 61.7% | 72.3% |
| UICCII (n = 112; 32.0%) | 63 (56.2%) | 49 (43.8%) | 73.5 (21–92) | 71 (63.4%) | 62% | 66.2% |
| UICC III (n = 87; 24.9%) | 47 (54.0%) | 40 (46.0%) | 70.0 (40–88) | 65 (74.7%) | 43% | 53.8% |
| UICC IV (n = 76; 21.7%) | 54 (71.0%) | 22 (29.0%) | 70.0 (30–85) | 52 (68.4%) | 0% | 9.6% |
| Sample Properties (n = 315) | ||||||
| primary resected tumors | metastases | |||||
| Adenoma (n = 9) | 9 | / | ||||
| Adenocarcinoma (n = 306) | 262 | 44 | ||||
| Unsuccessful tissue acquisition (n = 107) | ||||||
| primary resected tumors | metastases | |||||
| Adenoma (n = 25) | 25 | / | ||||
| Adenocarcinoma (n = 82) | 72 | 10 | ||||
| CRC Metastases Characteristics (n = 44) | ||||||
| resection site | ||||||
| liver | lung | peritoneum | brain | lymph node | ||
| synchronous (n = 18) | 17 | 0 | 1 | 0 | 0 | |
| metachronous (n = 26) | 19 | 1 | 3 | 2 | 1 | |
| initial stage | UICC I | UICC II | UICC III | UICC IV | ||
| 5 | 4 | 10 | 7 | |||
| sets of primary tumor and one or more corresponding metastases | N = 20 | |||||
The biobank includes samples from 382 patients, who consented to donate one or more tissue sample. One patient presented with a secondary tumor during follow-up and was classified as two individual cases (HROC50). ◆ One Patient showed complete remission of a rectal carcinoma and was classified as UICC 0. Tissue acquisition failed due to small neoplasia size in 107 (25 adenomas, 72 carcinomas, and 10 metastases) cases.