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. 2019 Oct 15;11(10):1566. doi: 10.3390/cancers11101566

Figure 6.

Figure 6

Dynamic PAGES-HBC changes in longitudinal samples of primary, post-neoadjuvant trastuzumab treated, and recurrent tumors from a single patient. (A), Heat map of PAGES-HBC, white bar, Group 1 level expression; black bar, Group 2 level expression; * p = 0.03; ** p = 0.65. (B), Expression of the genes that are transiently upregulated in trastuzumab-treated sample, (C), Expression of the genes that are transiently downregulated in trastuzumab-treated sample. (D), Transient upregulation of PDCD1 (PD-1) and CD274 (PD-L1) in trastuzumab-treated sample. Post-T, post-trastuzumab; Met, metastasis.