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. 2019 Oct 31;18:1533033819882949. doi: 10.1177/1533033819882949

Figure 4.

Figure 4.

MiR-146a-5p is a potential upstream activator of HOTAIR in TNBC cells. Comparing to C and NC 2 controls, miR-146a-5p expression was significantly altered after transfection of mimic and inhibitor (A). Moreover, miR-146a-5p overexpression mediated the upregulated expression of HOTAIR, while miR-146a-5p inhibition mediated the downregulated expression of HOTAIR (B). Similarly, comparing to C and NC 2 controls, HOTAIR expression was also significantly altered after transfection of expression vector and siRNA (C). However, HOTAIR overexpression and knockdown failed to affect miR-146a-5p (D). *P < .05. C indicates control; NC, negative control; siRNA, small interfering RNA; TNBC, triple-negative breast cancer.