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. 2019 Oct 31;18:1533033819882949. doi: 10.1177/1533033819882949

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© The Author(s) 2019

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 5. — MiR-146a-5p promoted TNBC cell migration and invasion through HOTAIR. Transwell migration and invasion assays showed that, compared with control (C) and negative control (NC) groups, overexpression of miR-146a-5p and HOTAIR led to accelerated, while HOTAIR siRNA silencing and miR-146a-5p inhibitor led to inhibited migration (A) and invasion (B) of cells of TNBC cell lines BT-549 and HCC70 (P < .05). In addition, HOTAIR silencing attenuated the inhibitory effects of miR-146a-5p on cancer cell migration and invasion. (P < .05. TNBC indicates triple-negative breast cancer.