Figure 4.

Pathway enrichment analysis of metabolic biomarkers in HCC. The network map represents pathways strongly correlated to metabolic dysfunction in HCC. Enrichment pathway analysis was based on the Kyoto Encyclopedia of Genes and Genomes database. All the represented metabolic pathways have FDR-adjusted p-values of less than 0.001. The sizes of the red circle indicate fold enrichment. Solid and dotted red circles represent metabolic pathways with more than four and three metabolic hits, respectively. HCC, hepatocellular carcinoma; FDR, false discovery rate.