Table 2.
Test performance characteristics for the biomarker signature from the training and test set.
| Set | Group | Data Set | AUC (95% CI) | Biomarker Cutoff | Sensitivity % | Specificity % |
|---|---|---|---|---|---|---|
| Training | HCC vs NC | AFP | 0.98 (0.96–1.00) | 0.26 | 94.30 | 92.00 |
| Biomarker | 0.99 (0.98–1.00) | 0.48 | 96.20 | 98.00 | ||
| Biomarker+AFP | 1.00 (1.00–1.00) | 0.50 | 100.00 | 100.00 | ||
| Training | HCC vs LC | AFP | 0.75 (0.65–0.85) | 0.46 | 84.90 | 61.70 |
| Biomarker | 0.82 (0.73–0.91) | 0.49 | 79.20 | 78.70 | ||
| Biomarker+AFP | 0.85 (0.76–0.93) | 0.52 | 81.10 | 78.70 | ||
| Test | HCC vs LC | AFP | 0.78 (0.71–0.85) | 0.46 | 74.10 | 67.50 |
| Biomarker | 0.94 (0.91–0.98) | 0.49 | 82.70 | 91.30 | ||
| Biomarker+AFP | 0.97 (0.71–0.85) | 0.52 | 82.70 | 95.00 |
AUC, area under the receiver operating curve; CI, confidence interval; HCC, hepatocellular carcinoma; LC, liver cirrhosis; NC, normal control; AFP, α-fetoprotein.