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Functions of exosomes derived from cytotoxic immune cells. Exosomes derived from CD8+ T cells and natural killer (NK) cells express recognition receptors for antigens, MHC, or damage signals on target cells and contain cytotoxic mediators, such as perforin, granzymes, and TNF-α that can eliminate tumors or virus-infected targets. These exosomes can also be used as drug delivery systems or vaccines in cancer therapy.
