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. 2019 Oct 10;11(10):1531. doi: 10.3390/cancers11101531

Figure 1.

Figure 1

Prognostic value of mesothelin expression by pancreatic ductal adenocarcinoma (PDAC) patients for survival. (A) Expression of mesothelin in tumoral (T) and nontumoral (NT) pancreatic tissues from The Cancer Genomic Atlas (TCGA) and Genomic Tissue-Expression (GTEx) datasets. The red and gray boxes represent PDAC and nontumoral-derived tissues, respectively (T: n = 179 and NT: n = 171). (B) Kaplan–Meier plots of overall survival probability (plotted on Y-axis) of PDAC cancer patients is shown (TCGA data, n = 177). Patients have been stratified into high (red lines, n = 59) or low (black lines, n = 118) expression-based “risk-groups” by their gene expression of mesothelin. The patient follow-up is indicated in months on the X-axis. Respective log-rank test p-value, HR, and computed median survivals of low and high expression cohorts in months are shown and were calculated at the best auto-selected cut-off. (C) Violin plot showing the average gene expression levels of mesothelin at early (I and II) and advanced (III and IV) cancer stages of PDAC patients (TCGA database, n = 179). * p < 0.05.