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FN prevents oxidative stress and DNA damage in MTX-administered rats. FN reduced reactive oxygen species (ROS) (A), thiobarbituric acid reactive species (TBARS) (B), nitric oxide (NO) (C) and 8-Oxo-2′-deoxyguanosine (8-Oxo-dG) (D) in the kidney of rats which received MTX. Data are mean ± SEM, (n = 6). *p < 0.05 and ***p < 0.001.
