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. 2019 Oct 11;11(10):1536. doi: 10.3390/cancers11101536

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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PGE₂ levels were significantly lower in colorectal cancer (n = 49), compared to the adjacent normal tissue samples (* p < 0.01) (A). PTGS1 (COX-1) and PTGS2 (COX-2) mRNA levels were significantly lower across COAD and READ tumors compared to the normal mucosa (TCGA and GTEx). On the other hand, PTGES3 (COX-3) and TERT mRNA levels were significantly upregulated in the tumors (B). TERT activity decreased from right to left colon, and rectum cancers; conversely, PGE₂ levels increased respectively (p = 0.006) (C). TERT expression was inversely correlated with the expression of PTGS1 and PTGS2, but not with the expression of PTGES3 in the TCGA-COAD dataset (D).