Figure 6.

KRAS mutations do not affect the expression of PTGS2 (COX-2) (A) or TERT (B). PTGS2 (COX-2) expression, on the other hand, is significantly higher among BRAF^mut COAD tumors carrying mainly missense/in frame and a few deleterious mutations, compared to the BRAF^wt ones (C). KRAS, a Kirsten ras oncogene homolog from the mammalian ras gene family, encoding a protein belonging to the small GTPase superfamily; BRAF, B-Raf proto-oncogene, serine/threonine kinase; PTGS2, prostaglandin-endoperoxide synthase 2; TERT, telomerase reverse transcriptase.