Table 2.
PGE2 levels (pg/mL) in colorectal cancerous tissue and its adjacent mucosa. Colorectal cancer patients have been stratified according to different clinicopathological characteristics. Statistically significant p-values are highlighted in bold.
| Variable | Normal Mucosa | Cancer Tissue | ||||||
|---|---|---|---|---|---|---|---|---|
| No | Mean | SD | p-Value | No | Mean | SD | p-Value | |
| All cases | 35 | 2374.04 | 1695.081 | 34 | 1589.622 | 1075.305 | 0.013 | |
| Sex | ||||||||
| Male | 13 | 1976.704 | 1477.7668 | 13 | 2034.405 | 1305.7355 | ||
| Female | 22 | 2866.836 | 2109.3560 | 0.056 | 21 | 1314.280 | 822.6191 | 0.191 |
| Smoke | ||||||||
| No | 24 | 2374.842 | 1669.7945 | 24 | 1419.926 | 860.0917 | ||
| Yes | 8 | 2796.588 | 2498.2338 | 0.59 | 7 | 1667.929 | 1206.1716 | 0.545 |
| BMI | ||||||||
| <25 | 19 | 2244.542 | 1745.6862 | 19 | 1812.677 | 1191.0385 | ||
| ≥25 | 16 | 2882.578 | 2124.8944 | 0.336 | 15 | 1307.085 | 865.2102 | 0.177 |
| Duke’s stage | ||||||||
| A | 0 | 0 | ||||||
| B | 16 | 3273.561 | 2036.8244 | 15 | 1696.322 | 904.9637 | ||
| C | 15 | 1930.935 | 1782.8859 | 15 | 1423.153 | 1294.7909 | ||
| D | 4 | 1856.634 | 1055.7880 | 4 | 1813.756 | 900.6809 | ||
| A+B | 16 | 3273.561 | 2036.8244 | 0.036 | 15 | 1696.322 | 904.9637 | 0.615 |
| C+D | 19 | 1915.293 | 1630.6619 | 19 | 1505.385 | 1210.7447 | ||
| Grade | ||||||||
| low | 4 | 2617.679 | 1318.3896 | 4 | 1261.628 | 802.6919 | ||
| moderate | 28 | 2682.486 | 2039.2589 | 27 | 1700.093 | 1127.0442 | ||
| high | 3 | 1062.409 | 859.9787 | 0.393 | 3 | 1032.711 | 868.3637 | 0.495 |
| Tumor site | ||||||||
| Right | 7 | 1667.951 | 1410.0214 | 7 | 936.412 | 523.005 | ||
| Left | 7 | 2929.321 | 2674.6937 | 7 | 2077.241 | 1396.8070 | ||
| Sigmoid | 10 | 2580.901 | 1377.0804 | 10 | 1536.713 | 1007.5961 | ||
| Rectum | 11 | 2797.966 | 2169.4357 | 0.236 | 10 | 1758.445 | 1090.7798 | 0.608 |
| Right colon | 7 | 1667.951 | 1410.0214 | 7 | 936.412 | 523.0055 | ||
| Left colon | 28 | 2753.282 | 1996.2152 | 0.186 | 27 | 1758.973 | 1122.4103 | 0.071 |
| Colon | 24 | 2416.246 | 1841.0003 | 24 | 1519.279 | 1084.3813 | ||
| Rectum | 11 | 2797.966 | 2169.4357 | 0.594 | 10 | 1758.445 | 1090.7798 | 0.563 |
| Ki-67 expression | ||||||||
| negative | 3 | 3617.660 | 2180.4306 | 3 | 1245.514 | 643.9262 | ||
| positive | 32 | 2434.830 | 1907.2952 | 0.449 | 31 | 1622.923 | 1109.6303 | 0.441 |
| p53 expression | ||||||||
| negative | 12 | 3271.839 | 1679.5463 | 12 | 1526.599 | 861.8398 | ||
| positive | 23 | 2152.412 | 1967.9908 | 0.09 | 22 | 1623.998 | 1193.4976 | 0.786 |