Table 1.
Tissue | Uptake Transporters | Export Transporters |
---|---|---|
Liver (cell type) | ||
Hepatocytes | From serum: OSTα/ß, NTCP, OATP | To bile: MRP2, MDR2, BSEP |
To serum: OSTα/ß, MRPs | ||
Cholangiocytes | From bile: ASBT | To serum: OSTα/ß |
Colon | From feces: ASBT | To serum: OSTα/ß |
Kidneys | From serum: ASBT | To serum/urine: MRP2, OSTα/ß |
NTCP, sodium taurocholate transporting polypeptide; MRP, multidrug resistance-associated protein; MDR, multidrug resistance protein; OST, organic solute transporters; ASBT, apical sodium-dependent bile acid transporters, organic anion-transporting polypeptide.