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. 2019 Sep 24;11(10):1421. doi: 10.3390/cancers11101421

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Influence of rSPARC on cancer cell migration. Cancer cells were seeded on collagen I coated plates supplemented with either PBS or PBS + rSPARC and tracked for a total of 22 h. Tracks were transformed to have the same starting points, and HCT116 as well as SW480 cells migrating on either collagen (A,B) or collagen + rSPARC (C,D) were plotted. Average migration speed in µm/min are shown for each well (n = 18) for a total of 3 independent experiments for HCT116 (E) and SW480 (F); statistical analyses were performed by using the Mann-Whitney test. *: p < 0.05; ****: p < 0.0001. Scatter dot plots: center line, means; whiskers, SD; rSPARC, human recombinant SPARC; PBS, phosphate buffered saline.