Table 2.
Summary data of the discriminative capacity of the serum 6-miRNA signature or faecal haemoglin concentration from ROC curve analysis, and values from combination of both. AUC: area under the curve; CI: confidence interval; SN: sensitivity; SP: specificity; PPV: positive predictive value; NPV: negative predictive value. AA: Advanced adenomas; CRC: Colorectal cancer; CRCAA: advanced colorectal neoplasia.
| Groups Compared | Serum 6-miRNA Signature | Faecal Hemoglobin Concentration | Serum 6-miRNA Signature + Faecal Haemoglobin Concentration | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AUC (95% CI) |
SN (%) | SP (%) | PPV (%) | NPV (%) | AUC (95% CI) |
SN (%) | SP (%) | PPV (%) | NPV (%) | AUC (95% CI) |
SN (%) | SP (%) | PPV (%) | NPV (%) | |
| CRC versus Control | 0.74 (0.65–0.82) |
81 | 56 | 58 | 79 | 0.85 (0.78–0.91) |
81 | 73 | 69 | 84 | 0.88 (0.83–0.94) |
81 | 78 | 74 | 84 |
| AA versus Control | 0.80 (0.72–0.87) |
81 | 63 | 68 | 77 | 0.65 (0.56–0.73) |
81 | 35 | 54 | 67 | 0.81 (0.75–0.88) |
81 | 69 | 71 | 79 |
| CRCAA versus Control | 0.76 (0.69–0.82) |
80 | 57 | 76 | 62 | 0.73 (0.67–0.8) |
80 | 55 | 75 | 63 | 0.82 (0.76–0.88) |
80 | 68 | 81 | 66 |