Figure 4.

Chronic histopathology of adolescent rCHI. (a) Representative image and (b) quantification of Iba1+ cells in 3HD and sham groups. (c) Representative image and (d) quantification of GFAP+ cells in 3HD and sham groups. (e) Representative image and (f) quantification of NeuN+ cells in cortex. (g) Representative image and (h) quantification of CMI+ area in corpus callosum. (i) Representative image and (j) quantification of DAPI+ cells in brain regions analyzed. No differences were observed in any of the aforementioned parameters between sham- and 3HD- injured mice. Additionally, no differences were observed between groups in (k) cortex (Cx) volume, (l) hippocampus (Hip) volume, and (m) lateral ventricle volume. For all assessments, n = 5/group. CC: corpus callosum; Str: striatum.