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. 2019 Oct 14;11(10):1561. doi: 10.3390/cancers11101561

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Double-strand break (DSB) repair mechanisms in quiescent and proliferating cells and major proteins participating in them. RAD52 as a potential target for synthetic lethality-based therapy has been marked in red. poly(ADP-ribose) polymerase 1 inhibitors (PARP1) and Polθ—promising partners for dual synthetic lethality have been marked in green.