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. 2019 Oct 9;11(10):1514. doi: 10.3390/cancers11101514

Figure 1.

Figure 1

Kaplan-Meier plots for the overall survival (OS) (A) and progression-free survival (PFS) (B) in lung adenocarcinoma (LADC) patients according to V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) mutation status. (A) LADC patients with KRAS wild-type (WT) tumors and receiving bevacizumab/chemotherapy (BEV/CHT) had significantly increased median OS (vs. those with KRAS WT tumors and receiving CHT only; median OS 21.57 vs. 14.23 months, respectively, p = 0.0186, log-rank test). Median OS was also increased in KRAS-mutant LADC patients receiving BEV/CHT compared to those treated with CHT only (median OSs were 18 vs. 10 months, respectively, p = 0.0002, log-rank test). No significant differences in OS have been observed for patients receiving CHT only and with KRAS WT versus KRAS-mutant tumors (median OSs were 11 vs. 10 months, respectively p = 0.6771, log-rank test). Of note, in the BEV/CHT group, patients with KRAS WT LADC had a significantly better OS than those with tumors harboring KRAS mutations (median OSs were 39 vs. 18 months, respectively, p = 0.0186, log-rank test). (B) Similarly, in the BEV/CHT group, patients with KRAS WT LADC had significantly longer median PFS (vs. those with KRAS-mutant tumors; median PFSs were 8.63 vs. 7.03 months, respectively, p = 0.0255, log-rank test).