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Circulating mutational fraction (CMF) distribution between clinical subgroups. (A) Difference between NON-LIVER (5 pts) and LIVER POSITIVE (9 pts) metastatic colorectal cancer (mCRC) (p = 0.0385). (B) Difference between patients with baseline CEA levels below (7 pts) or above (7 pts) median (p = 0.0469). *: p < 0.05. NON-LIVER: patients with no evidence of liver metastases. LIVER POSITIVE: all the patients with at least one liver metastasis (the sum of LIVER ONLY and LIVER and OTHER).
