Fig. 5.
MOG35–55 EAE in C57Bl/6J (n = 17) vs. sham-immunized (n = 12) mice. a EAE clinical scores. b Decreased visual acuity of EAE mice compared to untreated C57Bl/6J mice. OKR measurement was carried out for 120 days after MOG immunization as described above, area under the curve compared by ANOVA with Dunnett’s post hoc test. c–f Thickness of retinal layers. h–l RGC count after 9 months. Data expressed as mean ± SEM, *P < 0.05; **P < 0.01; ***P < 0.001. P values for OCT and RGC data obtained from generalized estimating equation models accounting for within-mouse, inter-eye correlations. m–r Linear regression analyses. IRL thickness during EAE is associated with ultimate neuronal loss (top row) and disease severity (bottom row). Similar results were obtained 5 and 7 months after immunization (data not shown). ß, generalized estimating equation association coefficient