Table 1.

Baseline characteristics

	Total	2015	2016	p-value
Number of patients	9518	4814	4704
Number of hospitals	75	75	74
Patient characteristics
Age in years (mean,sd)	71.0 (13.7)	70.9 (13.9)	71.0 (13.6)	0.77
Women (n, %)	4297 (46.0%)	2207 (46.4%)	2090 (45.5%)	0.39
Median onset-to-door time (IQR)	71.0 (45–119)	71.0 (45–119)	71.0 (45–119)	0.89
Hospital factors
Admission to comprehensive stroke center	3079 (32.3%)	1619 (33.6%)	1460 (31.0%)	0.01
Admission during off-hours	4696 (49.2%)	2358 (49.0%)	2328 (49.5%)	0.64
Median door-to-needle time (IQR)	26.0 (20–37)	27.0 (20–37)	25.0 (19–35)	< 0.001
Outcome measure
In-hospital mortality	561 (5.9%)	296 (6.2%)	265 (5.6%)	0.29