Table 2. Risk for Schizophrenia According to Mean Daily NO₂ Exposure During Childhood and Polygenic Risk Score in a Cohort of 23 355 Individuals.

Model	Childhood NO2 Exposure, AHR (95% CI)a	Polygenic Risk Score, AHR (95% CI)b
Model 1c	1.26 (1.19-1.34)	1.31 (1.26-1.36)
Model 2d	1.27 (1.19-1.35)	1.29 (1.23-1.35)
Model 3e	1.23 (1.15-1.32)	1.29 (1.23-1.34)

Abbreviations: AHR, adjusted hazard ratio; NO₂, nitrogen dioxide.

^aThe estimate for childhood NO₂ measures the increased risk of schizophrenia associated with a 10-μg/m³ increase in mean daily exposure to NO₂ during the first 10 years of life.

^bThe estimate for polygenic risk score measures the increased risk of schizophrenia associated with a 1-SD increase in polygenic risk score. The estimate was also adjusted for the first 10 genomic principal components.

^cAdjusted for age, sex, and birth year.

^dAdjusted for age, sex, birth year, parental history of psychiatric disorder, and parental socioeconomic position.

^eAdjusted for age, sex, birth year, parental history of psychiatric disorder, and parental socioeconomic position. The AHR for childhood daily NO₂ exposure was also adjusted for the polygenic risk score, and the AHR for polygenic risk score was also adjusted for childhood daily NO₂ exposure.