Figure 7.

Schematic representation of Dscam-regulated antimicrobial activities in crab. Dscam's cytoplasmic tail can generate four isoforms via alternative splicing, with all isoforms able to bind to the SH3 domain in the Dock protein because ofthe SH3-binding domain in the first constant exon. Dock then promotes ERK phosphorylation via indirect binding and regulates dorsal phosphorylation and translocation from the hemocyte's cytoplasm to nucleus. This enables dorsal to regulate the expression of AMPs in E. sinensis crabs.