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. 2019 Sep 18;294(44):16429–16439. doi: 10.1074/jbc.RA119.009006

Figure 1.

Figure 1.

Identification of USP17 as a novel deubiquitinase of SET8. A, COS7 cells were transiently transfected with HA-SET8 in the presence of FLAG-Strep-USPs. After 24 h, cell lysates were immunoblotted (IB) with the indicated antibodies. B, quantitative analysis of the HA-SET8 protein bands shown in Fig. S1. Data in the bar graph are the means and standard deviations (n = 3). **, p < 0.01. C, COS7 cells were transiently transfected with the indicated constructs. After 24 h, cell lysates were subjected to Strep-Tactin pulldown and immunoblotting with an anti-HA antibody.