Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Sep 21;9(10):244. doi: 10.3390/brainsci9100244

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

The time course of nicotine and cotinine in male B6J and B6N mice. The rate of nicotine metabolism is not significantly different in the B6J and B6N substrains. Nicotine metabolism was measured by quantifying the production of cotinine after drug administration. Mice were subcutaneously injected with nicotine (1 mg/kg) and had their blood collected at 5, 15, 30, and 60 min after injection. Nicotine levels were measured at 5, 15, 30, 60 min time points. Each time point represents the mean + SEM of six mice per group.