Table 1.

A summary of nicotine’s potency in the tail-flick, hot plate, body temperature and locomotor activity tests after acute administration in male B6J and B6N mice. Potency is expressed as the ED50 ± confidence limits (mg/kg). Each group contained 8 mice. * CL of ED50 values do not overlap.

Test	B6J (mg/kg)	B6N (mg/kg)
Tail flick	1.3 (0.56–1.89)	5.9 (3.1–11.23) *
Hot plate	1.08 (0.83–1.38)	7.79 (3.56–13.41) *
Body temperature	0.57 (0.37–0.88)	1.15 (0.96–2.13) *