Table 2.
Summary of pharmacokinetic parameters after acute nicotine administration (1 mg/kg, s.c.) in male B6J and B6N mice. Statistical comparisons were performed using two-tailed t-test. N.S = Not significant.
| Nicotine | Cotinine | ||||||
|---|---|---|---|---|---|---|---|
| Mean (SE) | AUC0-90 (min ng/mL) |
AUC0-inf (min ng/mL) |
Cmax (ng/mL) |
T1/2 (min) |
AUC0-90 (min ng/mL) |
AUC0-inf (min ng/mL) |
Cmax (ng/mL) |
| 6N | 4610 (126) |
5200 (136) |
216 (20.6) |
17.2 (1.43) |
5740 (384) |
7230 (713) |
129 (12.9) |
| 6J | 4930 (380) |
5880 (741) |
206 (30) |
20.5 3.68 |
7000 (418) |
8780 (506) |
131 (7.16) |
| Comparison | N.S. | N.S. | N.S. | N.S. | P = 0.05 | N.S. | N.S. |