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. 2019 Nov 1;213(3):723–757. doi: 10.1534/genetics.119.302333

Figure 4.

Figure 4

Rectal-to-neuron transdifferentiation. Rectal Y-to-PDA neuron Td occurs through a succession of discrete steps, including a dedifferentiation step, where the cell is stripped of its initial rectal identity without acquiring more cellular potential, followed by apparent step-wise redifferentiation into the PDA neuron. This succession of cellular steps is mirrored at the molecular level by step-specific combinations of histone modifier complexes (outlined in dashed green), such as JMJD-3.1 and the SET-1/MLL complex, and transcription factor complexes (outlined in dashed blue) such as a NODE-like + SOX-2 complex, and the UNC-3/COE TF.