Table 2.
Top 40 significantly (by FDR) differentially expressed genes of characterized proteins between high- and low-ADG steers from Angus, Charolais, and Kinsella Composite populations
| Angus | Charolais | Kinsella Composite | ||||||
|---|---|---|---|---|---|---|---|---|
| Gene | log2FC1 | FDR2 | Gene | Log2FC1 | FDR2 | Gene | log2FC1 | FDR2 |
| TMEM45A | −3.87 | 4.69E-76 | TMEM45A | −1.81 | 2.08E-19 | IFI27 | −2.69 | 9.87E-39 |
| SERPINA3 | 3.32 | 1.74E-55 | HOPX | −1.63 | 5.59E-16 | LPIN1 | −2.54 | 1.48E-34 |
| GPX3 | 2.94 | 1.75E-53 | AKR1B15 | 1.59 | 1.66E-14 | IFI6 | −1.67 | 5.27E-15 |
| AKR1B15 | 2.68 | 2.33E-38 | TNC | −1.73 | 2.20E-13 | SERPINA3 | 1.56 | 1.01E-14 |
| GPNMB | 1.85 | 3.79E-21 | HLA-DQB1 | −1.86 | 6.68E-13 | ISG15 | −1.59 | 8.76E-14 |
| HP | 2.43 | 8.42E-18 | GPC3 | −1.64 | 3.17E-12 | HBB | −1.49 | 8.54E-13 |
| S100A2 | 1.58 | 1.09E-15 | KEL | 1.53 | 1.19E-11 | HERC6 | −1.44 | 2.45E-12 |
| SERPINA3 | 1.95 | 7.74E-15 | DDO | −1.90 | 2.07E-10 | GNMT | −1.42 | 2.57E-12 |
| HOPX | 1.43 | 1.32E-14 | GPX3 | −2.20 | 2.72E-10 | GADD45G | −1.35 | 6.14E-11 |
| IFI6 | −1.47 | 1.96E-13 | SERPINA3 | 2.45 | 3.14E-10 | SLC5A8 | 1.75 | 9.76E-10 |
| UGT2B7 | −1.35 | 4.93E-13 | AC108941.2 | −1.55 | 3.09E-09 | CES1 | 1.24 | 5.26E-09 |
| IFI27 | −1.42 | 2.42E-12 | IGLV2-18 | −1.60 | 3.17E-08 | SERPINI2 | 1.29 | 3.15E-08 |
| GPC3 | −1.37 | 1.83E-11 | CYP2B6 | 1.29 | 4.48E-08 | CYP7A1 | 1.44 | 4.51E-08 |
| HMGCS1 | −1.30 | 2.50E-10 | SLC25A45 | 1.80 | 1.42E-07 | TSKU | −1.24 | 1.43E-07 |
| SECTM1 | 1.19 | 4.95E-10 | SERPINA3 | −1.61 | 1.97E-07 | IFIT1 | −1.38 | 1.43E-07 |
| SULT2A1 | 1.18 | 7.65E-10 | IGLV2-18 | −1.44 | 3.27E-07 | UHRF1 | −1.60 | 2.15E-07 |
| SPIDR | 1.20 | 7.83E-10 | SCD | −1.26 | 3.28E-07 | BOLA-DQA5 | −1.29 | 2.72E-06 |
| IGHG1 | 1.17 | 2.32E-08 | S100A10 | −1.14 | 4.06E-07 | NOCT | −1.10 | 3.39E-06 |
| ECEL1 | 1.10 | 5.27E-08 | STS | −1.12 | 7.69E-07 | WFDC2 | −1.03 | 4.29E-06 |
| JAKMIP2 | 1.44 | 9.89E-08 | UHRF1 | −1.47 | 1.48E-06 | ZNF385B | 1.19 | 4.29E-06 |
| CYP51A1 | −1.12 | 1.57E-07 | CCDC80 | −1.41 | 4.63E-06 | MX2 | −1.26 | 6.20E-06 |
| AIF1L | 1.02 | 2.62E-07 | SLC13A2 | −1.21 | 5.92E-06 | RSAD2 | −1.01 | 6.91E-06 |
| AKR1C1 | 1.22 | 2.91E-07 | EGR1 | −1.33 | 6.60E-06 | GSTM2 | −1.07 | 9.32E-06 |
| CCL24 | 1.35 | 4.38E-07 | CRYAB | −1.04 | 7.08E-06 | C12orf45 | −1.01 | 1.15E-05 |
| DLK1 | −1.28 | 4.54E-07 | HIST1H2BI | −0.99 | 7.11E-06 | IGFBP1 | 0.97 | 1.50E-05 |
| VCAM1 | −1.28 | 2.21E-06 | GNMT | −0.90 | 3.75E-05 | EXTL1 | 0.96 | 2.94E-05 |
| MT1G | 1.07 | 6.21E-06 | EPCAM | −1.05 | 8.16E-05 | ALAS1 | −1.00 | 3.46E-05 |
| SQLE | −0.99 | 1.05E-05 | IFI27 | −0.90 | 9.13E-05 | STS | −0.95 | 4.15E-05 |
| IL1R2 | 1.09 | 2.69E-05 | ACSS2 | −0.88 | 1.24E-04 | PLEKHG6 | 1.11 | 1.36E-04 |
| SERPINE1 | 0.88 | 4.03E-05 | SLC17A9 | 0.92 | 1.31E-04 | LURAP1L | −1.02 | 1.65E-04 |
| SLC13A2 | 0.91 | 5.28E-05 | SCD | −1.29 | 1.37E-04 | PRAP1 | −0.93 | 1.92E-04 |
| SERPINI2 | −1.21 | 5.40E-05 | THNSL2 | 0.91 | 2.19E-04 | SCD | −0.95 | 2.95E-04 |
| TNFRSF10A | −1.21 | 7.39E-05 | RCL1 | −0.88 | 2.30E-04 | FKBP5 | −0.89 | 5.62E-04 |
| RAP1GAP | 0.96 | 7.48E-05 | MID1IP1 | −0.85 | 2.42E-04 | TAT | −1.02 | 6.56E-04 |
| OXER1 | −0.84 | 8.35E-05 | MBOAT2 | −1.24 | 2.42E-04 | FGF21 | 0.95 | 6.85E-04 |
| SLC1A2 | −0.88 | 1.25E-04 | SOAT2 | 1.30 | 3.09E-04 | ACE2 | −0.84 | 7.03E-04 |
| MAMDC2 | −1.08 | 1.25E-04 | FOXA3 | −0.84 | 3.13E-04 | MX1 | −0.87 | 7.98E-04 |
| DENND2A | 0.82 | 1.50E-04 | MAMDC2 | −1.09 | 4.79E-04 | IFI44L | −0.83 | 8.80E-04 |
| ROS1 | −1.09 | 1.83E-04 | REC8 | −0.84 | 7.97E-04 | WFS1 | 0.81 | 1.24E-03 |
| CLBA1 | 1.15 | 2.55E-04 | ISG15 | −0.78 | 9.07E-04 | ALOX15B | 1.15 | 1.64E-03 |
1log2FC = log2(fold change of a gene in high-average daily gain [ADG] animals with reference to low-ADG animals).
2FDR = false discovery rate adjusted P-value.