Table 3.
Top 40 significantly (by FDR) differentially expressed genes of characterized proteins between high- and low-DMI steers from Angus, Charolais, and Kinsella Composite populations
| Angus | Charolais | Kinsella Composite | ||||||
|---|---|---|---|---|---|---|---|---|
| Gene | log2FC1 | FDR2 | Gene | log2FC1 | FDR2 | Gene | log2FC1 | FDR2 |
| IFIT1 | −2.49 | 1.38E-34 | SLC22A2 | 4.47 | 1.92E-47 | IFI27 | 3.13 | 9.17E-50 |
| GPX3 | −2.38 | 1.42E-30 | REC8 | −2.61 | 1.22E-37 | CXCL9 | 2.82 | 2.83E-44 |
| GPNMB | −2.23 | 4.16E-27 | EGR1 | 2.38 | 3.46E-31 | GBP3 | 2.99 | 3.15E-41 |
| HBB | 2.97 | 3.93E-26 | IGLC1 | 2.48 | 3.46E-31 | IFI6 | 2.24 | 1.09E-27 |
| SERPINA3 | −1.90 | 1.24E-20 | IGHG1 | 2.31 | 3.95E-28 | CYP2B6 | −2.17 | 1.62E-27 |
| ISG15 | −1.83 | 1.04E-17 | SERPINA3 | 2.47 | 3.92E-26 | HERC6 | 2.07 | 1.07E-25 |
| SFRP2 | 1.72 | 9.15E-17 | CCDC80 | 2.25 | 1.56E-23 | IFIT1 | 2.35 | 3.23E-25 |
| HERC6 | −1.44 | 1.18E-11 | SFRP1 | −1.79 | 1.00E-18 | ISG15 | 2.03 | 3.28E-23 |
| DDO | −1.63 | 3.99E-10 | GPX3 | 2.08 | 6.20E-17 | CXCL10 | 2.22 | 1.06E-22 |
| FKBP5 | 1.37 | 7.10E-10 | BOLA-DQB | −2.11 | 5.26E-16 | TMEM45A | −2.84 | 1.63E-22 |
| RSAD2 | −1.35 | 1.01E-09 | CLDN15 | 1.61 | 4.46E-15 | MX2 | 2.07 | 4.80E-20 |
| SDS | 1.36 | 1.82E-09 | ABCG8 | 1.54 | 2.98E-14 | AK4 | 1.79 | 2.11E-19 |
| APOA4 | 1.29 | 6.27E-09 | CES1 | −1.52 | 2.20E-12 | CD274 | 2.44 | 7.13E-16 |
| MBOAT2 | −1.28 | 7.41E-09 | S100A10 | 1.41 | 1.49E-11 | SERPINA3 | −1.60 | 2.60E-15 |
| CDHR5 | −1.25 | 7.65E-09 | CYP11A1 | 1.41 | 2.03E-11 | AKR1B15 | −1.75 | 7.10E-14 |
| MX1 | −1.26 | 1.44E-08 | NNAT | 1.63 | 8.45E-11 | OAS1 | 1.44 | 1.49E-12 |
| IL20RA | −1.32 | 4.02E-08 | FGF21 | 1.43 | 6.40E-10 | GBP7 | 1.71 | 2.55E-11 |
| SLC2A5 | 1.28 | 1.40E-07 | AC108941.2 | 1.50 | 8.82E-10 | RSAD2 | 1.36 | 2.55E-11 |
| STEAP4 | 1.19 | 2.94E-07 | CYR61 | 1.32 | 1.15E-09 | MKI67 | 1.45 | 4.35E-11 |
| GNMT | 1.10 | 1.18E-06 | PRAP1 | 1.26 | 1.73E-09 | PSMB9 | 1.46 | 7.64E-11 |
| MYOM1 | 1.21 | 2.78E-06 | CUX2 | 1.41 | 2.73E-09 | KYAT1 | −1.21 | 1.03E-08 |
| GPC3 | 1.06 | 7.85E-06 | CARNS1 | 1.27 | 3.43E-09 | IFI44L | 1.15 | 1.01E-07 |
| SERPINA3 | −1.31 | 1.98E-05 | TNC | 1.32 | 4.57E-09 | RTP4 | 1.17 | 1.01E-07 |
| HP | −1.52 | 2.27E-05 | SLC7A2 | −1.26 | 6.17E-09 | ATP6V1C2 | −1.66 | 2.12E-07 |
| LPIN1 | 1.03 | 2.27E-05 | HMGCS1 | −1.26 | 2.55E-08 | RBP5 | −1.12 | 3.20E-07 |
| SECTM1 | 1.02 | 2.28E-05 | IL1R2 | 1.48 | 3.82E-08 | GBP3 | 1.31 | 5.23E-07 |
| SCD | −0.99 | 3.23E-05 | LPIN1 | −1.23 | 4.91E-08 | HAPLN3 | −1.14 | 9.08E-07 |
| NR1D1 | −0.96 | 3.32E-05 | CDH17 | 1.13 | 1.82E-07 | CTGF | 1.49 | 1.29E-06 |
| CREM | 0.96 | 3.57E-05 | HP | 1.61 | 3.99E-07 | PSMB8 | 1.04 | 2.77E-06 |
| PYROXD2 | 0.98 | 4.35E-05 | IGLV2-18 | 1.29 | 6.43E-07 | TAP1 | 1.02 | 4.52E-06 |
| RTP4 | −0.93 | 8.43E-05 | ABCG5 | 1.16 | 6.55E-07 | FOXS1 | 1.45 | 7.19E-06 |
| SCD | −0.95 | 9.57E-05 | SLC4A4 | −1.08 | 9.88E-07 | PIM1 | −1.00 | 8.79E-06 |
| RNF125 | 0.96 | 1.20E-04 | IFI27 | −1.13 | 1.19E-06 | WFS1 | −0.99 | 9.48E-06 |
| IFI44L | −0.91 | 2.21E-04 | CLDN4 | 1.47 | 2.00E-06 | IFIT2 | 1.41 | 1.53E-05 |
| NOCT | 0.92 | 2.59E-04 | FOS | 1.21 | 2.91E-06 | NLRC5 | 1.05 | 2.76E-05 |
| CYP7A1 | −0.88 | 3.43E-04 | HOOK1 | −1.04 | 2.91E-06 | UBA7 | 0.97 | 2.77E-05 |
| AKR1B15 | −0.94 | 4.51E-04 | SQLE | −1.09 | 3.37E-06 | RAB20 | −0.96 | 3.20E-05 |
| DDIT4 | 0.91 | 4.80E-04 | STRIP2 | −1.03 | 3.92E-06 | CITED4 | 0.96 | 3.20E-05 |
| SPTB | −0.83 | 9.02E-04 | IGLC1 | 1.15 | 4.94E-06 | RRM2 | 1.36 | 3.20E-05 |
| CKAP4 | −0.83 | 9.42E-04 | DLK1 | 1.19 | 5.02E-06 | IL20RA | 1.13 | 3.33E-05 |
1log2FC = log2(fold change of a gene in low-daily dry matter intake [DMI] animals with reference to high-DMI animals).
2FDR = false discovery rate adjusted P-value.